Nostra
1. Do you find it reasonable to "Enable hotkeys" as an option in Preferences, not enabled by design as the default?
Most people, I believe, doesn't use, or can't remember all hotkeys. Especially when "common" and widely used hotkeys in other software or Windows, do something completely different in PVD ("Esc", for example). And especially when unintentionally pressing some key combination: sometimes the action is irreversible and the damage is big. Not to speak about uncredited hotkeys...
2. If "Yes" under 1. do you find it reasonable to enable setting our own combination of hotkeys?
Me personally, find it useful enabling CTRL+E to edit the movie in any version of PVD, for example (CTRL+SHIFT+S for "Save as...", CTRL+N for "New Movie Master" instead of New record, because we all use "New" very, very rarely, etc, etc). I'm used to use it.
Both suggestions, at least, are common for any third-party software, as I'm aware of it.